TRENBOLONE ACETATE

Trenbolone Acetate 100 is an oil based solution of trenbolone acetate for IM injection.
Trenbolone is an anabolic steroid with significant anabolic and androgenic effects. The fast
acting ester produces a rapid increase in serum trenbolone levels which remain elevated for
several days thereafter. Trenbolone promotes significant increases in strength, muscle
anabolism, appetite, and aggression; and has been demon- strated to reduce body fat.

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Description

Trenbolone Acetate

Strength: 100mg/ml
Molecular Formula: C20H2403,
Molecular Weight: 312.40276 g/mol
Active Ingredient: Trenbolone acetate
CAS number: 10161-34-9
Dosage Form: Injectable, oil base sterile solution
Route: Injection
Market Status: Prescription
Company: Hilma Biocare

DESCRIPTION

Trenbolone Acetate 100 is an oil based solution of trenbolone acetate for IM injection.
Trenbolone is an anabolic steroid with significant anabolic and androgenic effects. The fast
acting ester produces a rapid increase in serum trenbolone levels which remain elevated for
several days thereafter. Trenbolone promotes significant increases in strength, muscle
anabolism, appetite, and aggression; and has been demon- strated to reduce body fat.

INDICATIONS

Males: Trenbolone use may be indicated in patients where substantial weight gain and
increases in musculature are required for patient health after substantial losses of body
mass, especially in instances where caloric intake is limited and other anabolic therapies
have previously must consider the risks of therapy failed. The physician and patient versus
the potential benefits

CLINICAL PHARMACOLOGY

Anabolic steroids are synthetic derivatives of testosterone. Certain clinical effects and
adverse reactions demonstrate the androgenic properties of these drugs. Complete
dissociation of anabolic and androgenic effects has not been achieved. The actions of
anabolic steroids are thus similar to those of male sex hormones. Anabolic steroids suppress
the gonadotropic functions of the pituitary and may exert a direct effect upon the testes.
During exogenous administration of anabolic androgens, endogenous testosterone release
is inhibited through inhibition of pituitary luteinizing hormone (LH). At large doses,
spermatogenesis may be suppressed through feedback inhibition of pituitary folliclestimulating hormone (FSH). Trenbolone binds strongly to the androgen receptor and its
action is generally considered to derive therefrom. It produces significant anabolism even
during periods or limited caloric restriction. The literature offers conflicting reports of the
susceptibility of trenbolone to aromatize estrogen or reduce to a dihydrotestosterone
derivative. Rat studies have suggested that trenbolone may exert effects typically associated
with dihydrotestosterone through a non-DHT pathway potentially with direct receptor action.
It has been suggested that trenbolone may reduce cortisol production through an
indeterminate pathway of activity upon glucocorticoid receptors. Trenbolone has been
demonstrated to promote muscle growth, appetite, aggression, and the production of red
blood cells through the production of erythropoietic stimulating factors. Trenbolone is
suspected of selective binding of the progesterone receptor potentially acting as both an
agonist and an antagonist. It has been suggested that trenbolone is capable of binding to the
prolactin receptor. Thus serum progesterone and serum prolactin levels should be monitored
during treatment and if elevated anti-progesterone and anti-prolactin agents should be
considered.

ADVERSE REACTIONS

Male: Gynecomastia, excessive frequency and duration of penile erections, oligospermia.
Skin and Appendages: Hirsutism, male pattern baldness and acne, gynecomastia.
Fluid/electrolyte Disturbances: Retention of sodium, chloride water, potassium, calcium and
inorganic phosphates.

Gastrointestinal: Nausea. cholestatic jaundice, alterations in liver function tests;
hepatocellular neoplasms, peliosis hepatitis. hepatic adenomas, nephritis, and cholestatic
hepatitis.

Hematologic: Suppression of clotting factors IIl, V, VII, & X: bleeding in patients on anticoagulant therapy. Neurological: Increased libido, headache, anxiety, depression, extreme
agitation, irritability, and generalized paresthesia. Trenbolone may cause severe aggressive
behavior.

Other: Serum lipid changes. hs hypertension, hypercalcaemia, hypertension, oedema,
priapism, and potentiation of sleep apnea.

DRUG INTERACTIONS

Patients on oral anticoagulant therapy require close monitoring especially when androgens
are started or stopped.

Diabetics: androgens may alter the metabolism of oral hypoglycemic agents or may change
insulin sensitivity in patients with diabetes mellitus which may require adjustment of dosage
of insulin and other hypoglycemic drugs.

May alter metabolism of cyclosporine. Avoid other hepatotoxic medications.

CONTRAINDICATIONS

Patients with known hypersensitivity to any ingredients in this product. Patients with known
or suspected carcinomas of the breast, testis, or prostate. Patients with severe heart
disease, liver disease, or kidney disease or with a history of epilepsy. Products containing
androgens should not be used in women as they may cause virilization and fetal harm.

PRECAUTIONS

Women, children and elderly males should not use. Trenbolone should be used with extreme
caution and with the lowest dosage and duration of treatment necessary for clinical response
pursuant to the advice of a qualified physician. Because androgens may alter serum
cholesterol concentration, caution should be used when administering these drugs to
patients with a history of myocardial infarction or coronary artery disease. Trenbolone may
increase aggressiveness and cause psychiatric changes. At the first sign of psychiatric
changes discontinue use of trenbolone and contact a physician. Due to its hepatotoxicity,
liver functions should be monitored. Discontinue on signs of jaundicing. PATIENT
MONITORING Serum Cholesterol, HDL, LDL, TG. Hemoglobin and Hematocrit, Hepatic
function tests – AST/ALT. Prostatic specific antigen – PSA, Testosterone: total, free, and
bioavailable. Dihydrotestosterone & Estradiol. Progesterone, Prolactin, Blood Pressure. Male
patients over 40 should undergo a digital rectal examination and evaluate PSA prior to
androgen use. Periodic evaluations of the prostate should continue while on androgen
therapy, especially in patients with difficulty in urination or with changes in voiding habits.

DOSAGE AND ADMINISTRATION

Adult male: 50 – 100 mg injected IM every 3 days for duration limited to 4 weeks under care
of physician.

PRESENTATION

Trenbolone Acetate 100 mg/ml, 10 ml multiple dose vial.

STORAGE

Store in a cool dry place between 15 – 25°C.Protect from light.

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